In this issue paper, Gordon DeJong and Michele Steinmetz of the Population Research Institute at The Pennsylvania State University, focus on the so-called “brain drain” migration in Pennsylvania — the gain or loss of young and highly educated working-age adults through the exchange of migration with other states. An objective of this report is to document the migration flow of one of Pennsylvania’s most valuable resources — its best and brightest workers — during the 1995-2001 period.